Apolipoprotein E4 allele frequency, ischemic cerebrovascular disease, and Alzheimer's disease.
نویسندگان
چکیده
منابع مشابه
Apolipoprotein E4 allele frequency, ischemic cerebrovascular disease, and Alzheimer's disease.
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متن کاملThe Apolipoprotein E e4 Allele and Outcome in Cerebrovascular Disease
Background and Purpose—Polymorphism of the apolipoprotein E gene (APOE) may influence outcome after traumatic brain injury and intracerebral hemorrhage, with the e4 allele being associated with poorer prognosis. We investigated APOE allele distribution in acute stroke and the effect of the e4 allele on outcome. Methods—APOE genotypes were determined in 714 stroke patients: 640 ischemic stroke a...
متن کاملPrevalence of Apolipoprotein E Phenotypes in Ischemic Cerebrovascular Disease
coronary artery disease. We investigated the putative role of apolipoprotein E phenotypes in cerebral infarction. Methods: The apolipoprotein E phenotypes of 69 patients (mean±SD age, 72±+11 years) who had suffered completed stroke or a transient ischemic attack and 68 sexand age-matched control subjects free of cerebrovascular disease were determined by isoelectric focusing. The relative frequ...
متن کاملIschemic Cerebrovascular Disease
Background and Purpose: The relation between the redistribution phenomenon and regional cerebral blood flow and its clinical significance were investigated in stroke patients. Methods: Single-photon emission computed tomography studies using N-isopropyl-p-[1u31]iodoamphetamine were performed on 16 patients (26 to 77 years old) with chronic infarction and 10 age-matched normal control subjects. ...
متن کاملConfirmation of association between the e4 allele of apolipoprotein E and Alzheimer's disease.
The Apo E genotype of 86 patients with Alzheimer's disease (AD) and 77 age matched controls was determined by digestion of Apo E PCR products with the restriction enzyme CfoI. The frequency of the e4 allele was significantly increased in the patient group (0.33) as compared with controls (0.12). This effect was seen in patients with a family history and in sporadic cases. The odds ratio in homo...
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ژورنال
عنوان ژورنال: Stroke
سال: 1993
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.24.9.1416